Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.
Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.
Autoimmun Rev. 2017 Oct;16(10):1044-1048. doi: 10.1016/j.autrev.2017.07.021. Epub 2017 Aug 1.
Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. This review focuses on recent studies in DM/PM research based on multi-omics. This integrated analysis of multi-omics profiling will provide useful insights into DM/PM pathogenesis and recommendations for therapeutic targets and biomarkers development.
特发性炎性肌病（IIM）是一组罕见且异质性的自身免疫性疾病，最常见的亚型是皮肌炎（DM）和多发性肌炎（PM）。尽管已经做了大量努力，但是 IIM 的潜在机制仍不清楚。最近，为了理解 IIM 的发病机制，人们已经进行了基因组学、表观遗传学、转录组学、蛋白质组学和自身抗体研究。这篇综述重点关注基于多组学的 DM/PM 研究的最新研究。对多组学图谱的综合分析将为 DM/PM 的发病机制提供有用的见解，并为治疗靶点和生物标志物的开发提供建议。
