Glück Z, Reubi F C
Eur J Clin Pharmacol. 1986;31(1):107-11. doi: 10.1007/BF00870997.
The acute effects of bisoprolol 10 mg i.v., a new beta1-selective adrenoceptor antagonist, on heart rate, mean blood pressure (mBP), glomerular filtration rate (GFR), para-aminohippuric acid clearance (CPAH), sodium clearance, urine volume and plasma renin activity (PRA), were studied in 6 patients with essential hypertension. Heart rate decreased by 23%, mBP remained unchanged, and GFR decreased by 14% and CPAH by 23%. PRA was depressed on average by 25%. Urine volume and sodium clearance also declined by 9 and 13%, respectively, but the changes were not statistically significant. The fall in heart rate was significantly correlated with that in GFR and CPAH. Changes in GFR were correlated significantly with those in CPAH. The acute changes in renal function induced by bisoprolol are considered to be due to a reduction in cardiac output and increased systemic vascular resistance.
在6例原发性高血压患者中研究了新型β1选择性肾上腺素能受体拮抗剂比索洛尔静脉注射10 mg对心率、平均血压（mBP）、肾小球滤过率（GFR）、对氨基马尿酸清除率（CPAH）、钠清除率、尿量和血浆肾素活性（PRA）的急性影响。心率下降23%，mBP保持不变，GFR下降14%，CPAH下降23%。PRA平均降低25%。尿量和钠清除率也分别下降了9%和13%，但这些变化无统计学意义。心率下降与GFR和CPAH下降显著相关。GFR的变化与CPAH的变化显著相关。比索洛尔引起的肾功能急性变化被认为是由于心输出量减少和全身血管阻力增加所致。
