Wilkinson R, Stevens I M, Pickering M, Robson V, Hawkins T, Kerr D N, Harry J D
Br J Clin Pharmacol. 1980 Jul;10(1):51-9. doi: 10.1111/j.1365-2125.1980.tb00501.x.
1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in total body potassium during treatment with either drug. 4 Ambulant plasma renin activity was reduced by both drugs but the fall in blood pressure was not related to initial plasma renin. 5 Despite equal mean reduction in blood pressure with the two drugs, creatinine clearance fell significantly only during treatment with propranolol. 6 These observations suggest that intra-renal beta 2-adrenoceptors may be of importance in the regulation of renal function.
已经对15名原发性高血压患者进行了一项交叉研究，随机给予普萘洛尔和阿替洛尔，研究了它们的效果。
两种药物都能有效降低血压，且副作用没有明显差异。
使用这两种药物治疗期间，可交换钠、钾或总体钾均无变化。
两种药物都降低了动态血浆肾素活性，但血压下降与初始血浆肾素无关。
尽管两种药物平均降压效果相同，但仅在使用普萘洛尔治疗期间肌酐清除率显著下降。
这些观察结果表明，肾内β2 -肾上腺素能受体可能在肾功能调节中起重要作用。
