阿替洛尔和普萘洛尔对原发性高血压患者肾功能影响的研究。
A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension.
作者信息
Wilkinson R, Stevens I M, Pickering M, Robson V, Hawkins T, Kerr D N, Harry J D
出版信息
Br J Clin Pharmacol. 1980 Jul;10(1):51-9. doi: 10.1111/j.1365-2125.1980.tb00501.x.
Abstract
1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in total body potassium during treatment with either drug. 4 Ambulant plasma renin activity was reduced by both drugs but the fall in blood pressure was not related to initial plasma renin. 5 Despite equal mean reduction in blood pressure with the two drugs, creatinine clearance fell significantly only during treatment with propranolol. 6 These observations suggest that intra-renal beta 2-adrenoceptors may be of importance in the regulation of renal function.
摘要
已经对15名原发性高血压患者进行了一项交叉研究，随机给予普萘洛尔和阿替洛尔，研究了它们的效果。
两种药物都能有效降低血压，且副作用没有明显差异。
使用这两种药物治疗期间，可交换钠、钾或总体钾均无变化。
两种药物都降低了动态血浆肾素活性，但血压下降与初始血浆肾素无关。
尽管两种药物平均降压效果相同，但仅在使用普萘洛尔治疗期间肌酐清除率显著下降。
这些观察结果表明，肾内β2 -肾上腺素能受体可能在肾功能调节中起重要作用。
相似文献
1
A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension.阿替洛尔和普萘洛尔对原发性高血压患者肾功能影响的研究。
Br J Clin Pharmacol. 1980 Jul;10(1):51-9. doi: 10.1111/j.1365-2125.1980.tb00501.x.
2
A comparison of the antihypertensive effect of atenolol (ICI 66 082) and propranolol.阿替洛尔（ICI 66 082）与普萘洛尔降压效果的比较。
Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):361-5. doi: 10.1007/BF00606549.
3
Effects of propranolol and atenolol on blood pressure and plasma renin activity in patients with moderate hypertension.普萘洛尔和阿替洛尔对中度高血压患者血压及血浆肾素活性的影响。
S Afr Med J. 1977 Nov 19;52(22):875-9.
4
5
Effects of atenolol and propranolol when added to long-term antihypertensive diuretic therapy.阿替洛尔和普萘洛尔添加至长期降压利尿治疗时的效果。
Clin Pharmacol Ther. 1979 Oct;26(4):420-7. doi: 10.1002/cpt1979264420.
6
Effects of oral atenolol and propranolol on blood pressure, heart rate and plasma cyclic adenosine 3':5'-monophosphate in borderline hypertensive patients.口服阿替洛尔和普萘洛尔对临界高血压患者血压、心率及血浆环磷腺苷3':5'-单磷酸的影响。
Pharmacology. 1982;25(1):33-8. doi: 10.1159/000137721.
7
Response to atenolol in arterial hypertension in relation to renal function, pharmacokinetics and renin activity.阿替洛尔治疗动脉高血压的疗效与肾功能、药代动力学及肾素活性的关系
Postgrad Med J. 1977;53 Suppl 3:134-41.
8
9
Comparison of the effects of xamoterol, atenolol and propranolol on breathlessness, fatigue and plasma electrolytes during exercise in healthy volunteers.健康志愿者运动期间，比较羟甲异丁肾上腺素、阿替洛尔和普萘洛尔对呼吸急促、疲劳及血浆电解质的影响。
Eur J Clin Pharmacol. 1991;41(1):51-5. doi: 10.1007/BF00280106.
10
The relationship between beta-blockade, hyporeninaemic and hypotensive effect of two beta-blocking agents.两种β受体阻滞剂的β受体阻滞作用、低肾素血症及降压作用之间的关系。
Postgrad Med J. 1976;52 Suppl 4:102-8.
引用本文的文献
1
Cardiorenal Systems Modeling: Left Ventricular Hypertrophy and Differential Effects of Antihypertensive Therapies on Hypertrophy Regression.心肾系统建模：左心室肥厚以及抗高血压疗法对肥厚消退的不同影响
Front Physiol. 2021 Jun 16;12:679930. doi: 10.3389/fphys.2021.679930. eCollection 2021.
2
How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure.抗高血压药物如何发挥作用？来自动脉血压肾脏调节研究的见解。
Front Physiol. 2016 Jul 29;7:320. doi: 10.3389/fphys.2016.00320. eCollection 2016.
3
Diabetic nephropathy. Its relationship to hypertension and means of pharmacological intervention.糖尿病肾病。其与高血压的关系及药物干预方法。
Drugs. 1997 Aug;54(2):197-234. doi: 10.2165/00003495-199754020-00002.
4
Labetalol and renal function.拉贝洛尔与肾功能
Ir J Med Sci. 1981 Jun;150(6):174-7. doi: 10.1007/BF02938228.
5
Labetolol in patients with hypertension and varying degrees of renal impairment.拉贝洛尔用于患有高血压及不同程度肾功能损害的患者。
Ir J Med Sci. 1984 Oct;153(10):336-42. doi: 10.1007/BF02939928.
6
Beta-blockers and renal function.β受体阻滞剂与肾功能
Drugs. 1982 Mar;23(3):195-206. doi: 10.2165/00003495-198223030-00002.
7
Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists.β-肾上腺素能受体拮抗剂对安替比林代谢的抑制作用。
Br J Clin Pharmacol. 1981 Dec;12(6):779-84. doi: 10.1111/j.1365-2125.1981.tb01306.x.
8
Effects of dilevalol, an R, R-isomer of labetalol, on blood pressure and renal function in patients with mild-to-moderate essential hypertension.拉贝洛尔的R，R-异构体二利洛尔对轻至中度原发性高血压患者血压及肾功能的影响。
Eur J Clin Pharmacol. 1988;35(1):9-15. doi: 10.1007/BF00555500.
9
Acute changes in renal function induced by bisoprolol, a new cardioselective beta-blocking agent.新型心脏选择性β受体阻滞剂比索洛尔引起的肾功能急性变化。
Eur J Clin Pharmacol. 1986;31(1):107-11. doi: 10.1007/BF00870997.
10
Renal effects of pinacidil in hypertensive patients on chronic beta-blocker therapy.吡那地尔对接受慢性β受体阻滞剂治疗的高血压患者的肾脏影响。
Eur J Clin Pharmacol. 1986;30(6):641-7. doi: 10.1007/BF00608209.
本文引用的文献
1
Effect of propranolol, a beta-adrenergic antagonist, on blood flow in the coronary and other vascular fields.β-肾上腺素能拮抗剂普萘洛尔对冠状动脉及其他血管区域血流的影响。
Am Heart J. 1967 Feb;73(2):207-16. doi: 10.1016/0002-8703(67)90150-0.
2
[Beta-receptors and renal hemodynamics in humans].[人类的β受体与肾血流动力学]
Arzneimittelforschung. 1966 Jul;16(7):847-50.
3
Mechanism of increased sodium reabsorption during propranolol administration.普萘洛尔给药期间钠重吸收增加的机制。
Circulation. 1971 Oct;44(4):596-604. doi: 10.1161/01.cir.44.4.596.
4
Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases.普萘洛尔对肾素分泌的抑制作用。一种诊断和治疗肾素依赖性高血压疾病的特定方法。
N Engl J Med. 1972 Dec 14;287(24):1209-14. doi: 10.1056/NEJM197212142872401.
5
Deterioration in renal function after beta-blockade in patients with chronic renal failure and hypertension.慢性肾衰竭合并高血压患者使用β受体阻滞剂后肾功能恶化。
Br Med J. 1974 Apr 27;2(5912):193-4. doi: 10.1136/bmj.2.5912.193.
6
Plasma volume changes with long-term beta-adrenergic blockade.长期β-肾上腺素能阻滞剂治疗会导致血浆容量变化。
Am Heart J. 1971 Dec;82(6):770-6. doi: 10.1016/0002-8703(71)90198-0.
7
Effects of cyclic AMP, sympathomimetic amines, and adrenergic receptor antagonists on renin secretion.环磷酸腺苷、拟交感胺及肾上腺素能受体拮抗剂对肾素分泌的影响。
Circ Res. 1971 Sep;29(3):239-48. doi: 10.1161/01.res.29.3.239.
8
Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.一种用于血管紧张素I的放射免疫测定法在正常人体血浆肾素活性生理测量中的应用。
J Clin Endocrinol Metab. 1969 Oct;29(10):1349-55. doi: 10.1210/jcem-29-10-1349.
9
Changes in glomerular filtration rate during long-term treatment with propranolol in patients with arterial hypertension.普萘洛尔长期治疗高血压患者期间肾小球滤过率的变化
Clin Sci. 1973 Feb;44(2):129-34. doi: 10.1042/cs0440129.
10
Letter: Beta-adrenergic blocking agents in renal failure.信函：肾衰竭中的β-肾上腺素能阻滞剂。
Br Med J. 1974 Aug 24;3(5929):520. doi: 10.1136/bmj.3.5929.520-a.
Zotero 插件