Department of Clinical Application of Biologics, Osaka University Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8):a028456. doi: 10.1101/cshperspect.a028456.
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses. However, dysregulated excessive and persistent synthesis of IL-6 has a pathological effect on, respectively, acute systemic inflammatory response syndrome and chronic immune-mediated diseases. The IL-6 inhibitor, tocilizumab, a humanized anti-IL-6 receptor antibody, is currently being used for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, and Castleman disease. Lines of recent evidence strongly suggest IL-6 blockade can provide broader therapeutic strategy for various diseases included in acute systemic and chronic inflammatory diseases.
白细胞介素 6(IL-6)是维持内环境稳定的典型细胞因子。当内环境稳态被感染或组织损伤打破时,IL-6 会立即产生,并通过激活急性期和免疫反应来帮助宿主抵御这种紧急应激。然而,IL-6 的过度且持续失调合成会对急性全身性炎症反应综合征和慢性免疫介导性疾病分别产生病理性影响。IL-6 抑制剂,托珠单抗,一种人源化抗 IL-6 受体抗体,目前正被用于治疗类风湿关节炎、幼年特发性关节炎和 Castleman 病。最近的一些证据表明,IL-6 阻断可能为包括急性全身性和慢性炎症性疾病在内的各种疾病提供更广泛的治疗策略。