Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Ouhai, China.
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Neurol Sci. 2017 Oct;38(10):1859-1863. doi: 10.1007/s10072-017-3068-5. Epub 2017 Aug 4.
Neutrophil to lymphocyte ratio (NLR) was introduced to assess the activity in autoimmune diseases. Neuromyelitis optica spectrum disorder (NMOSD) has been defined as a chronic inflammatory disease with a course of relapse-remission. Therefore, the relationship between NLR and NMOSD was assessed in this article. Data of NMOSD patients was extracted. NLR is calculated as the absolute count of neutrophil divided by the absolute count of lymphocytes. Correlations between NLR and characteristics of NMOSD patients were evaluated. Effect of treatments on NLR was also analyzed. Increased level of NLR was observed in patients with NMOSD compared healthy individuals (p < 0.001); moreover, patients who were experiencing acute attack had a higher level of NLR compared with those who in remission (p < 0.001). NLR was correlated with RDW (r = 0.288, p = 0.021), ΔEDSS (r = 0.301, p = 0.016). NLR may be a helpful marker to assess the disease activity of NMOSD. Meanwhile, NLR may reflect the aggravated degree of neurological disability.
中性粒细胞与淋巴细胞比值（NLR）被引入以评估自身免疫性疾病的活动度。视神经脊髓炎谱系疾病（NMOSD）已被定义为具有复发缓解病程的慢性炎症性疾病。因此，本文评估了 NLR 与 NMOSD 之间的关系。提取 NMOSD 患者的数据。NLR 计算为中性粒细胞的绝对计数除以淋巴细胞的绝对计数。评估 NLR 与 NMOSD 患者特征之间的相关性。还分析了治疗对 NLR 的影响。与健康个体相比，NMOSD 患者的 NLR 水平升高（p<0.001）；此外，处于急性发作期的患者的 NLR 水平高于缓解期的患者（p<0.001）。NLR 与 RDW（r=0.288，p=0.021）、ΔEDSS（r=0.301，p=0.016）相关。NLR 可能是评估 NMOSD 疾病活动度的有用标志物。同时，NLR 可能反映了神经功能障碍加重的程度。
