Yılmaz Hakan, Yılmaz Özlem, Çamlıdağ İlkay, Belet Ümit, Akan Hüseyin
Department of Radiology, Hitit University, Çorum Training and Research Hospital, Çorum, Turkey.
Department of Dermatology, Hitit University, Çorum Training and Research Hospital, 19200, Çorum, Turkey.
Jpn J Radiol. 2017 Oct;35(10):590-596. doi: 10.1007/s11604-017-0672-5. Epub 2017 Aug 4.
The purpose of our study was to evaluate the efficacy of percutaneous sclerotherapy using bleomycin in treatment of lymphatic malformations.
Between January 2009 and January 2013, ten patients with lymphatic malformations who were admitted to the interventional radiology department were included in this retrospective study. Intralesional bleomycin was administered by percutaneous injection through 21-23 Gauge needles with a dose of 1 mg/kg body weight. Patients were clinically and radiologically assessed at baseline and followed at first and third months after treatment. Response to treatment was measured visually by using photographs and by radiological images. Symptomatic improvement was also evaluated either by patients or parents.
Excellent resolution was obtained visually in 80% of patients with lymphatic malformation. Significant resolution was achieved in 20% of patients. The percentage of radiographic resolution in size and the improvement in symptoms evaluated by patients or parents were similar with visual outcomes. No side effects were recorded except for fever in one patient and transient erythema in another patient.
Intralesional bleomycin is a safe and effective treatment for patients with lymphatic malformations.
本研究的目的是评估使用博来霉素进行经皮硬化治疗淋巴管畸形的疗效。
2009年1月至2013年1月期间，介入放射科收治的10例淋巴管畸形患者纳入本回顾性研究。通过21-23号针头经皮注射瘤内博来霉素，剂量为1mg/kg体重。在基线时对患者进行临床和影像学评估，并在治疗后的第一个月和第三个月进行随访。通过照片和影像学图像直观地测量治疗反应。患者或其父母也对症状改善情况进行了评估。
80%的淋巴管畸形患者在视觉上获得了极佳的消退效果。20%的患者实现了显著消退。通过影像学测量的大小消退百分比以及患者或其父母评估的症状改善情况与视觉结果相似。除1例患者发热和另1例患者出现短暂红斑外，未记录到其他副作用。
瘤内注射博来霉素对淋巴管畸形患者是一种安全有效的治疗方法。
