University College London Great Ormond Street Institute of Child Health, London, UK.
Department of Paediatric Endocrinology and Diabetes, Children's Hospital for Wales, Cardiff, UK.
Diabet Med. 2017 Dec;34(12):1710-1718. doi: 10.1111/dme.13442. Epub 2017 Aug 31.
To understand the scope for improving children's glycaemic outcomes by reducing variation between clinics and examine the role of insulin regimen and clinic characteristics.
Cross-sectional analysis of 2012-2013 National Paediatric Diabetes Audit data from 21 773 children aged < 19 years with Type 1 diabetes cared for at 176 clinics organized into 11 regional diabetes networks in England and Wales. Variation in HbA was explored by multilevel models with a random effect for clinic. The impact of clinic context was quantified by computing the per cent of total variation in HbA which occurs between clinics (intraclass correlation coefficient; ICC).
Overall, 69 of the 176 diabetes clinics (39%) had a glycaemic performance that differed significantly from the national average after adjusting for patient case-mix with respect to age, gender, diabetes duration, deprivation and ethnicity. However, differences between clinics accounted for 4.7% of the total variation in HbA . Inclusion of within-clinic HbA standard deviation led to a substantial reduction in ICC to 2.4%. Insulin regimen, clinic volume and diabetes networks had a small or moderate impact on ICC.
Differences between diabetes clinics accounted for only a small portion of the total variation in glycaemic control because most of the variation was within clinics. This implies that national glycaemic improvements might best be achieved not only by targeting poor centres but also by shifting the whole distribution of clinics to higher levels of quality.
通过减少诊所间的差异来提高儿童的血糖控制效果,并研究胰岛素治疗方案和诊所特征的作用。
对 2012-2013 年英格兰和威尔士 11 个区域糖尿病网络中 176 家诊所的 21773 名年龄<19 岁的 1 型糖尿病儿童的国家儿科糖尿病审计数据进行横断面分析。采用多水平模型对 HbA 的变异性进行分析,诊所为随机效应。通过计算 HbA 总变异中发生在诊所间的百分比(组内相关系数;ICC)来量化诊所环境的影响。
总体而言,在调整了患者年龄、性别、糖尿病病程、贫困程度和种族等病例组合因素后,176 家糖尿病诊所中有 69 家(39%)的血糖控制效果与全国平均水平显著不同。然而,诊所间的差异仅占 HbA 总变异的 4.7%。纳入诊所内 HbA 标准差后,ICC 显著降低至 2.4%。胰岛素治疗方案、诊所数量和糖尿病网络对 ICC 的影响较小或中等。
诊所间的差异仅占血糖控制总变异的一小部分,因为大部分变异是在诊所内发生的。这意味着,要提高全国的血糖控制水平,不仅要针对治疗效果较差的中心,还要努力提高整个诊所质量的分布水平。