Rutgers, New Jersey Medical School, Department of Medicine-Hematology-Oncology, Newark, NJ 07103, USA.
Rutgers, New Jersey Medical School, Department of Medicine-Hematology-Oncology, Newark, NJ 07103, USA.
Cell Immunol. 2018 Apr;326:33-41. doi: 10.1016/j.cellimm.2017.07.011. Epub 2017 Aug 1.
The immune modulatory properties of mesenchymal stem cells (MSCs) are mostly controlled by the particular microenvironment. Cancer stem cells (CSCs), which can initiate a clinical tumor, have been the subject of intense research. This review article discusses investigative studies of the roles of MSCs on cancer biology including on CSCs, and the potential as drug delivery to tumors. An understanding of how MSCs behave in the tumor microenvironment to facilitate the survival of tumor cells would be crucial to identify drug targets. More importantly, since CSCs survive for decades in dormancy for later resurgence, studies are presented to show how MSCs could be involved in maintaining dormancy. Although the mechanism by which CSCs survive is complex, this article focus on the cellular involvement of MSCs with regard to immune responses. We discuss the immunomodulatory mechanisms of MSC-CSC interaction in the context of therapeutic outcomes in oncology. We also discuss immunotherapy as a potential to circumventing this immune modulation.
间充质干细胞（MSCs）的免疫调节特性主要受特定微环境控制。癌症干细胞（CSCs）能够引发临床肿瘤，一直是研究的热点。本文综述了探讨 MSCs 在癌症生物学中作用的研究，包括对 CSCs 的作用，以及作为肿瘤药物递送的潜力。了解 MSCs 在肿瘤微环境中的行为如何促进肿瘤细胞的存活，对于确定药物靶点至关重要。更重要的是，由于 CSCs 在休眠状态下可以存活数十年，直到后来再次活跃，因此本文介绍了研究如何表明 MSCs 可能参与维持休眠状态。尽管 CSCs 存活的机制很复杂，但本文重点讨论了 MSCs 与免疫反应相关的细胞参与。我们讨论了 MSC-CSC 相互作用的免疫调节机制在肿瘤学治疗结果方面的意义。我们还讨论了免疫疗法作为规避这种免疫调节的潜在方法。
