乳腺癌干细胞、细胞因子网络与肿瘤微环境。
Breast cancer stem cells, cytokine networks, and the tumor microenvironment.
机构信息
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
J Clin Invest. 2011 Oct;121(10):3804-9. doi: 10.1172/JCI57099. Epub 2011 Oct 3.
Abstract
Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.
摘要
许多肿瘤，包括乳腺癌，都是由具有干细胞特性的细胞亚群维持的，这些细胞亚群介导转移，并导致治疗耐药。这些癌症干细胞（CSCs）受到与肿瘤微环境成分（包括间充质干细胞、脂肪细胞、肿瘤相关成纤维细胞、内皮细胞和免疫细胞）的复杂相互作用的调节，这些相互作用通过细胞因子和生长因子网络进行。由于这些成分对 CSC 特性有直接影响，因此它们是治疗开发的有吸引力的目标。
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