Madan Nandini, Carvalho Karen S
From the Section of Cardiology, Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA.
Section of Neurology, Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA.
Semin Pediatr Neurol. 2017 Feb;24(1):3-13. doi: 10.1016/j.spen.2017.01.001. Epub 2017 Jan 16.
This article focuses on the complex interactions between the cardiovascular and neurologic systems. Initially, we focus on neurological complications in children with congenital heart disease both secondary to the underlying cardiac disease and complications of interventions. We later discuss diagnosis and management of common syncope syndromes with emphasis on vasovagal syncope. We also review the diagnosis, classification, and management of children and adolescents with postural orthostatic tachycardia syndrome. Lastly, we discuss long QT syndrome and sudden unexpected death in epilepsy (SUDEP), reviewing advances in genetics and current knowledge of pathophysiology of these conditions. This article attempts to provide an overview of these disorders with focus on pathophysiology, advances in molecular genetics, and current medical interventions.
本文重点关注心血管系统与神经系统之间的复杂相互作用。首先，我们关注先天性心脏病患儿的神经并发症，这些并发症既继发于潜在的心脏疾病，也源于干预措施的并发症。随后，我们讨论常见晕厥综合征的诊断与管理，重点是血管迷走性晕厥。我们还回顾了体位性直立性心动过速综合征患儿及青少年的诊断、分类和管理。最后，我们讨论长QT综合征和癫痫性猝死（SUDEP），回顾这些病症在遗传学方面的进展以及当前的病理生理学知识。本文试图对这些疾病进行概述，重点关注病理生理学、分子遗传学进展以及当前的医学干预措施。
