Lee Min Young, Kim Doo Hee, Park Su-Kyoung, Jun Sang Beom, Lee Yena, Choi Jun-Jae, Yoo Hyun Ji, Raphael Yehoash, Oh Seung-Ha
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Republic of Korea; Kresge Hearing Research Institute, Otolaryngology - Head and Neck Surgery, The University of Michigan Medical School, United States; Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Republic of Korea; Interdisciplinary Program in Brain Science, College of Natural Sciences, Seoul National University, Republic of Korea.
Neurosci Lett. 2017 Sep 14;657:171-178. doi: 10.1016/j.neulet.2017.08.001. Epub 2017 Aug 2.
Hearing loss in mature ears can cause functional reorganization of the auditory cortex. The functional reorganization is speculated to negatively affect the outcome of hearing rehabilitation. Therefore, once hearing loss occurs, it is important to provide auditory input before extensive reorganization in the auditory pathways. We investigated the neural plasticity in auditory cortex after single-sided deafness (SSD) in an adult rat model. The animals were divided into two groups: a normal hearing (NH) and the SSD group. The neural recordings of the SSD group were conducted at different time points (2, 4, 6 and 8 weeks) after cochlear ablation. The multi-unit activity was discriminated on the sum of spikes, peak amplitude, onset latency, peak latency, and responsive area based on the peak amplitude. The auditory cortical reorganization was observed after SSD. The contralateral dominance of peak amplitude and latency that normally occur in NH group were not present in the SSD group, replaced by higher amplitude and faster response in ipsilateral cortex. According to serial recordings at different time points after SSD, different phases in the response of the auditory cortex were speculated. Compared with normal hearing, alteration of contralateral dominance was observed because of the functional reorganization of the auditory cortex after SSD.
成年耳朵的听力损失会导致听觉皮层的功能重组。据推测，这种功能重组会对听力康复的结果产生负面影响。因此，一旦发生听力损失，在听觉通路发生广泛重组之前提供听觉输入就很重要。我们在成年大鼠模型中研究了单侧耳聋（SSD）后听觉皮层的神经可塑性。将动物分为两组：正常听力（NH）组和SSD组。在耳蜗切除后的不同时间点（2、4、6和8周）对SSD组进行神经记录。基于峰值幅度，根据尖峰总和、峰值幅度、起始潜伏期、峰值潜伏期和反应区域来区分多单位活动。SSD后观察到听觉皮层重组。SSD组中不存在NH组中通常出现的峰值幅度和潜伏期的对侧优势，取而代之的是同侧皮层中更高的幅度和更快的反应。根据SSD后不同时间点的连续记录，推测了听觉皮层反应的不同阶段。与正常听力相比，SSD后听觉皮层的功能重组导致对侧优势发生改变。
