Departments of Neurobiology and Pharmacology/Toxicology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA.
Curr Opin Pharmacol. 2017 Aug;35:105-110. doi: 10.1016/j.coph.2017.07.012. Epub 2017 Aug 3.
Pharmacological treatment to prevent brain injury-induced temporal lobe epileptogenesis has been generally unsuccessful, raising the issues of exactly when the conversion process to an epileptic brain state occurs and reaches completion, and which cellular or network processes might be the most promising therapeutic targets. The time course of epileptogenesis is a central issue, with recent results suggesting that injury-induced epileptogenesis can be a much more rapid process than previously thought, and may be inconsistent with a delayed epileptogenic mechanism. Simplification of the seemingly complex issues involved in the use of epilepsy animal models might lead to a better understanding of the nature of injury-induced epileptogenesis, the significance of the 'latent' period, and whether current strategies should focus on preventing or modifying epilepsy.
预防脑损伤诱导的颞叶癫痫发生的药物治疗通常都不成功，这引发了一些问题，例如确切的转变过程在何时发生并完成，以及哪些细胞或网络过程可能是最有希望的治疗靶点。癫痫发生的时间进程是一个核心问题，最近的研究结果表明，损伤诱导的癫痫发生可能比之前认为的要快得多，并且可能与延迟的致痫机制不一致。对涉及癫痫动物模型使用的看似复杂的问题进行简化，可能有助于更好地理解损伤诱导的癫痫发生的本质、“潜伏”期的意义，以及当前的策略是否应该侧重于预防或改变癫痫。
