Giri Mohan, Shah Abhilasha, Upreti Bibhuti, Rai Jayanti Chamling
National Center for Rheumatic Diseases, Ratopul, Kathmandu 44600, Nepal.
Biomed Rep. 2017 Aug;7(2):105-114. doi: 10.3892/br.2017.927. Epub 2017 Jun 14.
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and it is the most common form of dementia in the elderly. Early onset AD is caused by mutations in three genes: () and . Late onset AD (LOAD) is complex and apolipoprotein E is the only unanimously accepted genetic risk factor for its development. Various genes implicated in AD have been identified using advanced genetic technologies, however, there are many additional genes that remain unidentified. The present review highlights the genetics of early and LOAD and summarizes the genes involved in different signaling pathways. This may provide insight into neurodegenerative disease research and will facilitate the development of effective strategies to combat AD.
阿尔茨海默病（AD）是一种异质性神经退行性疾病，是老年人中最常见的痴呆形式。早发性AD由三个基因的突变引起：（）和。晚发性AD（LOAD）较为复杂，载脂蛋白E是其发展过程中唯一被一致认可的遗传风险因素。使用先进的基因技术已经鉴定出了与AD相关的各种基因，然而，仍有许多其他基因尚未被鉴定出来。本综述重点介绍了早发性和晚发性AD的遗传学，并总结了参与不同信号通路的基因。这可能为神经退行性疾病研究提供见解，并将促进对抗AD的有效策略的发展。
