Neuro Aging Laboratory Group (NEURAL), Clinical Neurosciences Research Laboratories (LINCs), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
Int J Mol Sci. 2022 Jul 22;23(15):8082. doi: 10.3390/ijms23158082.
Alzheimer's disease (AD) is considered the most prevalent neurodegenerative disease and the leading cause of dementia worldwide. Sphingolipids, such as ceramide or sphingosine 1-phosphate, are bioactive molecules implicated in structural and signaling functions. Metabolic dysfunction in the highly conserved pathways to produce sphingolipids may lead to or be a consequence of an underlying disease. Recent studies on transcriptomics and sphingolipidomics have observed alterations in sphingolipid metabolism of both enzymes and metabolites involved in their synthesis in several neurodegenerative diseases, including AD. In this review, we highlight the most relevant findings related to ceramide and neurodegeneration, with a special focus on AD.
阿尔茨海默病（AD）被认为是最常见的神经退行性疾病，也是全球痴呆症的主要病因。神经酰胺或鞘氨醇 1-磷酸等神经鞘脂是参与结构和信号功能的生物活性分子。产生神经鞘脂的高度保守途径的代谢功能障碍可能导致或成为潜在疾病的后果。最近的转录组学和神经鞘脂组学研究观察到几种神经退行性疾病（包括 AD）中涉及合成的酶和代谢物的神经鞘脂代谢发生改变。在这篇综述中，我们重点介绍了与神经酰胺和神经退行性变相关的最相关发现，特别是 AD。
