Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.
Department of Cognitive, Linguistic & Psychological Sciences, Brown University, United States.
Neurosci Biobehav Rev. 2017 Sep;80:657-672. doi: 10.1016/j.neubiorev.2017.07.014. Epub 2017 Aug 3.
Parkinson's disease is a frequent neurodegenerative disease that is mostly known for its motor symptoms. However, cognitive impairment is now recognised as an important part of the disease. Studies of cognitive impairment in Parkinson's disease reveal considerable heterogeneity in terms of which cognitive domains are impaired, and of how cognitive impairment progresses over time. In parallel, a growing body of research reports language difficulties in Parkinson's disease, more specifically in the domains of sentence processing and lexical-semantic processing. In this review, the performance of patients with Parkinson's disease in these domains of language will be reviewed with a focus on the links that they have with the rest of cognition and on how they could contribute to the earlier and more precise characterization and prediction of cognitive impairment in Parkinson's disease. More specifically, the potential for modulation of complexity and sensitivity of language tasks to mild deficits and difficulties that are predictive of further decline will be emphasized. Other motivations for studying language difficulties in this disease will also be discussed.
帕金森病是一种常见的神经退行性疾病,其运动症状最为人所知。然而,认知障碍现在被认为是疾病的一个重要组成部分。对帕金森病认知障碍的研究表明,在哪些认知领域受损以及认知障碍随时间如何进展方面存在相当大的异质性。与此同时,越来越多的研究报告指出帕金森病存在语言困难,更具体地说,在句子处理和词汇语义处理领域存在语言困难。在这篇综述中,将重点关注语言领域的帕金森病患者的表现,以及它们与其他认知领域的联系,以及它们如何有助于更早、更准确地描述和预测帕金森病的认知障碍。更具体地说,将强调语言任务的复杂性和敏感性的调节潜力,以应对具有预测性的轻度缺陷和困难。还将讨论研究这种疾病中语言困难的其他动机。