Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea.
Eur J Neurol. 2017 Oct;24(10):1300-1306. doi: 10.1111/ene.13378. Epub 2017 Aug 7.
Elevated serum uric acid (UA) is known to be associated with stroke. However, there is little information on the association between serum UA levels and cerebral microbleed (CMB), a precursor of stroke. Therefore, we investigated the association between UA and CMB in a general population taking into consideration sex-related differences.
The subjects in this cross-sectional study consisted of 2686 individuals of 40-79 years of age (1403 men and 1283 women) who underwent regular health screenings, including brain magnetic resonance imaging, at Seoul National University Hospital Health Promotion Center. Subjects were categorized into three groups according to tertiles of UA levels by sex. The presence and location of CMB were assessed by gradient-recalled echo magnetic resonance imaging.
The prevalence of CMB was 3.8%. In multivariate logistic regression analysis by sex, the highest tertile of UA in male subjects was independently associated with the presence of CMB compared with the lowest tertile of UA (adjusted odds ratio, 2.46; P = 0.013). Meanwhile, the highest tertile of UA in female subjects was inversely associated with CMB compared with the lowest tertile of UA (adjusted odds ratio, 0.39; P = 0.040).
High serum UA value was associated with higher prevalence of CMB in male, but lower prevalence of CMB in female subjects.
已知血清尿酸（UA）升高与中风有关。然而，关于血清 UA 水平与中风前体——脑微出血（CMB）之间的关联信息较少。因此，我们在考虑性别差异的情况下，在一般人群中调查了 UA 与 CMB 之间的关联。
本横断面研究的对象为在首尔国立大学医院健康促进中心接受定期健康筛查的 2686 名 40-79 岁个体（男性 1403 名，女性 1283 名）。根据性别将 UA 水平分为三分位，将受试者分为三组。采用梯度回波磁共振成像评估 CMB 的存在和位置。
CMB 的患病率为 3.8%。在按性别进行的多变量逻辑回归分析中，与 UA 最低三分位相比，男性受试者 UA 的最高三分位与 CMB 的存在独立相关（调整后的优势比，2.46；P=0.013）。而女性受试者 UA 的最高三分位与 CMB 的存在呈负相关（调整后的优势比，0.39；P=0.040）。
高血清 UA 值与男性 CMB 患病率较高相关，而与女性 CMB 患病率较低相关。
