Bakthavatchalam Yamuna Devi, Nabarro Laura E B, Ralph Ravikar, Veeraraghavan Balaji
a Department of Clinical Microbiology , Christian Medical College , Vellore - 632004 , India.
b Department of Medicine (unit II) , Christian Medical College , Vellore - 632004 , India.
Virulence. 2017 Aug 7:0. doi: 10.1080/21505594.2017.1362532.
The incidence of invasive Staphylococcus aureus (SA) infection has increased in the past decade and is associated with poor outcomes and high mortality rates. Of all the virulence factors, Panton-Valentine Leukocidin (PVL) has received the greatest attention. PVL producing SA strains are more likely to produce severe skin and soft tissue infections (SSTIs) and necrotizing pneumonia. This review focuses on the current evidence on PVL-SA virulence, epidemiology, clinical disease and treatment with relevance to healthcare in India.
在过去十年中，侵袭性金黄色葡萄球菌（SA）感染的发生率有所上升，且与不良预后和高死亡率相关。在所有毒力因子中，杀白细胞素（PVL）受到的关注最多。产生PVL的SA菌株更易引发严重的皮肤和软组织感染（SSTIs）以及坏死性肺炎。本综述重点关注与印度医疗保健相关的关于PVL-SA毒力、流行病学、临床疾病及治疗的现有证据。
