Zhang Guo-Yan, Chen Yan-Li, Li Hai-Hong, Guan Zhi, He Yan-Hong
School of Chemistry and Chemical Engineering, Southwest University, Chongqing, PR China.
SLAS Discov. 2017 Oct;22(9):1162-1167. doi: 10.1177/2472555217724437. Epub 2017 Aug 7.
A crude extract from earthworms was used as an environmentally friendly and easily accessible biocatalyst for asymmetric direct aldol reactions. The β-hydroxy carbonyl compounds could be prepared in yields of up to 94%, with ee values of up to 98% and dr of up to >99:1. A wide range of substrates could participate in the reaction. This earthworm catalyst was also efficient in the large-scale reaction, providing product in excellent yield and good selectivity. The protocol as an example gives inspiration for the development of sustainable catalysts from nature, which also provides a potential possibility for application of earthworm catalyst in industrial production.
蚯蚓粗提物被用作一种环境友好且易于获取的生物催化剂，用于不对称直接羟醛反应。β-羟基羰基化合物的产率可达94%，对映体过量值（ee值）可达98%，非对映体比例（dr）可达>99:1。多种底物可参与该反应。这种蚯蚓催化剂在大规模反应中也很高效，能以优异的产率和良好的选择性提供产物。该方案作为一个例子，为开发天然可持续催化剂提供了灵感，也为蚯蚓催化剂在工业生产中的应用提供了潜在可能性。
