Allbrand Marianne, Åman Jan, Lodefalk Maria
a Department of Obstetrics and Gynecology, School of Medical Sciences , Örebro University , Örebro , Sweden.
b Department of Paediatrics, School of Medical Sciences , Örebro University , Örebro , Sweden.
J Matern Fetal Neonatal Med. 2018 Nov;31(21):2839-2846. doi: 10.1080/14767058.2017.1358262. Epub 2017 Aug 8.
The purpose of this study is to investigate placental ghrelin and leptin expression as well as cord blood ghrelin and adiponectin levels in maternal obesity and associations between placental ghrelin expression, cord blood ghrelin levels and maternal and infant variables.
Placental ghrelin and leptin expression were analyzed by RT-PCR in 32 severely obese and 32 matched normal-weight women. Cord blood ghrelin, adiponectin, leptin, and C-peptide concentrations were analyzed by ELISA.
Neither ghrelin nor leptin expression and neither cord blood ghrelin nor adiponectin levels differed between the groups. Placental ghrelin expression was associated with BMI at delivery in the obese women (r = 0.424, p = .016) and in the infants born to normal-weight women with their weight z-scores at six (r = -0.642, p = .010), nine (r = -0.441, p = .015), and 12 months of age (r = -0.402, p = .028).
Placental ghrelin and leptin expression as well as cord blood ghrelin and adiponectin levels do not seem to be altered in severe maternal obesity. Placenta-derived ghrelin may influence the infants' postnatal weight gain, but possibly only when the mother has normal weight.
本研究旨在调查母亲肥胖情况下胎盘生长激素释放肽和瘦素的表达，以及脐血中生长激素释放肽和脂联素水平，同时研究胎盘生长激素释放肽表达、脐血生长激素释放肽水平与母婴变量之间的关联。
采用逆转录聚合酶链反应（RT-PCR）分析32例严重肥胖女性和32例体重匹配的正常体重女性胎盘生长激素释放肽和瘦素的表达。采用酶联免疫吸附测定法（ELISA）分析脐血中生长激素释放肽、脂联素、瘦素和C肽的浓度。
两组间生长激素释放肽和瘦素的表达以及脐血中生长激素释放肽和脂联素的水平均无差异。肥胖女性分娩时胎盘生长激素释放肽表达与体重指数（BMI）相关（r = 0.424，p = 0.016），正常体重女性所生婴儿在6个月（r = -0.642，p = 0.010）、9个月（r = -0.441，p = 0.015）和12个月龄（r = -0.402，p = 0.028）时其胎盘生长激素释放肽表达与体重z评分相关。
严重母亲肥胖时，胎盘生长激素释放肽和瘦素的表达以及脐血中生长激素释放肽和脂联素的水平似乎未发生改变。胎盘来源的生长激素释放肽可能影响婴儿出生后的体重增加，但可能仅在母亲体重正常时才会如此。
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