Rydell E L, Axelsson K L, Olofsson J, Wikberg J E
ORL J Otorhinolaryngol Relat Spec. 1986;48(5):265-9. doi: 10.1159/000275880.
Cyclic nucleotides (cAMP, cGMP) are suggested to participate in the regulation of cell growth and differentiation. Guanylate cyclase is the enzyme which catalyzes the synthesis of cGMP. The basal guanylate cyclase activity was slightly higher in well-differentiated squamous cell carcinomas than in normal mucosa, but was two-fold higher in papillomas. Poorly differentiated squamous cell carcinoma did not show any increased basal activity. Stimulation with nitroprusside (NP) resulted in a 20% increased activity for normal mucosa and a 30% increase for poorly differentiated carcinomas, whereas enzyme prepared from well-differentiated squamous carcinomas and papillomas showed a two-fold increase.
环核苷酸（cAMP、cGMP）被认为参与细胞生长和分化的调节。鸟苷酸环化酶是催化cGMP合成的酶。高分化鳞状细胞癌的基础鸟苷酸环化酶活性略高于正常黏膜，但在乳头状瘤中则高出两倍。低分化鳞状细胞癌未显示基础活性有任何增加。用硝普钠（NP）刺激后，正常黏膜的活性增加20%，低分化癌增加30%，而高分化鳞状癌和乳头状瘤制备的酶活性增加两倍。
