Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven University and Hospital, Herestraat 49, 3000, Leuven, Belgium.
Crit Care. 2017 Aug 7;21(1):209. doi: 10.1186/s13054-017-1786-y.
Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose.
自噬是一种分解代谢过程，通过该过程，细胞可以处理受损内容物和细胞内微生物。最近的证据表明，自噬是一种关键的修复过程，对于从危重病引起的器官衰竭中恢复是必要的。在危重病的急性期停止肠外营养可以激活自噬并促进恢复。几种已注册的药物具有刺激自噬的特性，但都缺乏特异性，而且没有一种药物为此目的在危重病患者中进行过研究。
