动作电位持续时间对作为复极离散指标的T-T间期、T波面积和T波振幅的影响：兔心脏的理论与模拟研究
Effect of action potential duration on T-T interval, T-wave area and T-wave amplitude as indices of dispersion of repolarization: Theoretical and simulation study in the rabbit heart.
作者信息
Arteyeva Natalia V, Azarov Jan E
机构信息
Laboratory of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Branch, Russian Academy of Sciences, 50, Pervomayskaya st., Syktyvkar 167982, Russia.
Laboratory of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Branch, Russian Academy of Sciences, 50, Pervomayskaya st., Syktyvkar 167982, Russia; Department of Physiology, Medical Institute of Pitirim Sorokin Syktyvkar State University, 11, Babushkin st., Syktyvkar 167000, Russia.
出版信息
J Electrocardiol. 2017 Nov-Dec;50(6):919-924. doi: 10.1016/j.jelectrocard.2017.07.001. Epub 2017 Jul 11.
BACKGROUND
The aim of the study was to differentiate the effect of dispersion of repolarization (DOR) and action potential duration (APD) on T-wave parameters being considered as indices of DOR, namely, Tpeak-Tend interval, T-wave amplitude and T-wave area.
METHODS
T-wave was simulated in a wide physiological range of DOR and APD using a realistic rabbit model based on experimental data. A simplified mathematical formulation of T-wave formation was conducted.
RESULTS
Both the simulations and the mathematical formulation showed that Tpeak-Tend interval and T-wave area are linearly proportional to DOR irrespectively of APD range, while T-wave amplitude is non-linearly proportional to DOR and inversely proportional to the minimal repolarization time, or minimal APD value.
CONCLUSION
Tpeak-Tend interval and T-wave area are the most accurate DOR indices independent of APD. T-wave amplitude can be considered as an index of DOR when the level of APD is taken into account.
背景
本研究的目的是区分复极离散度（DOR）和动作电位时程（APD）对被视为DOR指标的T波参数的影响，即T峰 - T末间期、T波振幅和T波面积。
方法
基于实验数据，使用真实的兔模型在广泛的生理DOR和APD范围内模拟T波。对T波形成进行了简化的数学公式推导。
结果
模拟和数学公式推导均表明，无论APD范围如何，T峰 - T末间期和T波面积与DOR呈线性比例关系，而T波振幅与DOR呈非线性比例关系，且与最小复极时间或最小APD值呈反比。
结论
T峰 - T末间期和T波面积是最准确的独立于APD的DOR指标。当考虑APD水平时，T波振幅可被视为DOR指标。
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