Miyakawa T, Watanabe K, Katsuragi S
Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;52(2):99-106. doi: 10.1007/BF02889954.
Amyloid fibrils in brains of patients with Alzheimer's disease and Down's syndrome were examined by light and electron microscopy. In addition, replicas of amyloid fibrils produced by a quick freezing method from the brain of a patient with Down's syndrome were examined by electron microscopy. The amyloid fibrils were shown to consist of hollow rods. These were composed of filaments arranged as a tightly coiled helix, each turn of which consisted of five globular subunits. This structure appears to be similar to the prion filament observed in Creutzfeldt-Jakob disease (CJD). The possibility therefore arises that amyloid fibrils in Alzheimer's disease and Down's syndrome may be related to the transmissible agents responsible for diseases such as CJD, kuru and Gerstmann-Sträussler Syndrome (GSS).
采用光学显微镜和电子显微镜对阿尔茨海默病患者及唐氏综合征患者大脑中的淀粉样纤维进行了检查。此外，还通过电子显微镜对一名唐氏综合征患者大脑经快速冷冻法产生的淀粉样纤维复制品进行了检查。结果显示，淀粉样纤维由空心杆组成。这些空心杆由排列成紧密盘绕螺旋状的细丝构成，每一圈由五个球状亚基组成。这种结构似乎与在克雅氏病（CJD）中观察到的朊病毒细丝相似。因此，阿尔茨海默病和唐氏综合征中的淀粉样纤维有可能与导致诸如克雅氏病、库鲁病和格斯特曼-施特劳斯勒综合征（GSS）等疾病的传染性病原体有关。
