Waserstein M, Dacoll C, Cohen H, Gamboa L, Brener A, de Mizrahi J B, Sempol D, Neumark A, Nieto F, Tenzer S
Acta Gastroenterol Latinoam. 1985;15(4):243-55.
The aim of this work is to establish the best treatment for patients with gastric and duodenal ulcer, by measuring the effects of antiacids and H2-receptor antagonists on gastric pH. 16 patients were studied: 9 of them had a duodenal ulcer, 2 a gastric ulcer and 5 had both. All the patients remained fasting and receiving no drug for 24 hrs. During this 24 hrs., a nasogastric tube was inserted into the stomach and the gastric content was obtained by aspiration each hour from 8 A.M. to 8 P.M. Three days after, each patient received a daily dose of 1 g of Cimetidine, and the whole procedure was repeated. The same was done with 300 mg of Ranitidine daily, 150 ml of Al-Mg antiacids daily, and at last, the same procedure was performed with the association of Ranitidine and Al-Mg antiacids at the mentioned dosage. For the statistical analysis of the data, the mean ordinate of the pH was used as a representative value of each individual's pH. Individual differences (pH with treatment minus pH without treatment) were obtained. The mean effect of each treatment was obtained averaging that differences. For comparison among different drugs, the same procedure was used. Student's paired t tests were performed in a signification level. The buffering capacity was measured in the following way: The percentage of the gastric secretion samples with pH equal or higher than 4 in each treatment and in the total number of patients was confronted with the results obtained in the same patients with no treatment. All the drugs were useful for buffering the gastric acidity, but in different intensity. The association of Ranitidine and Al-Mg antiacids showed to be the most efficient statistically when compared with Cimetidine and Al-Mg antiacids; no statistical difference appeared in the comparison with Ranitidine.
这项工作的目的是通过测量抗酸剂和H2受体拮抗剂对胃pH值的影响，来确定治疗胃和十二指肠溃疡患者的最佳方法。研究了16名患者：其中9人患有十二指肠溃疡，2人患有胃溃疡，5人两者都有。所有患者均禁食且24小时未服用药物。在这24小时内，将一根鼻胃管插入胃中，从上午8点到晚上8点每小时通过抽吸获取胃内容物。三天后，每位患者每天服用1克西咪替丁，然后重复整个过程。每天服用300毫克雷尼替丁、每天服用150毫升铝镁抗酸剂时也进行同样的操作，最后，以上述剂量联合使用雷尼替丁和铝镁抗酸剂时进行相同的操作。对于数据的统计分析，pH值的平均纵坐标被用作每个个体pH值的代表值。获得个体差异（治疗后的pH值减去未治疗的pH值）。通过对这些差异求平均值获得每种治疗的平均效果。对于不同药物之间的比较，使用相同的程序。在显著水平上进行学生配对t检验。缓冲能力通过以下方式测量：将每种治疗以及所有患者中pH值等于或高于4的胃分泌样本的百分比与同一患者未治疗时获得的结果进行对比。所有药物都有助于缓冲胃酸，但强度不同。与西咪替丁和铝镁抗酸剂相比，雷尼替丁和铝镁抗酸剂联合使用在统计学上显示出最有效；与雷尼替丁相比，未出现统计学差异。
