Mlakar Polona, Salobir Barbara, Čobo Nusret, Strašek Janja, Prezelj Marija, Debevc Ana, Jug Borut, Terčelj Marjeta, Šabovič Mišo
Department of Pulmonary Diseases and Allergy, University Medical Center Ljubljana, Zaloška 7, 1000 Ljubljana, Slovenia.
Department of Preventive Cardiology and Vascular Medicine, University Medical Center Ljubljana, Zaloška 7, 1000 Ljubljana, Slovenia.
Int J Cardiol Heart Vasc. 2015 Feb 7;7:40-48. doi: 10.1016/j.ijcha.2015.02.003. eCollection 2015 Jun 1.
Chronic inflammation, the fundamental pathogenetic process of atherosclerosis, can be modified by pharmacological and non-pharmacological measures as a part of secondary prevention after acute myocardial infarction (AMI). The aim of our study was to determine the effect of diet, rich with natural antioxidants, added to physical activity (as a part of cardiac rehabilitation (CR) program) on inflammatory markers and ox-LDL, a marker of oxidative stress, closely involved in the process of chronic inflammation.
41 male patients after AMI undergoing CR were divided into a diet group (supervised cardioprotective diet throughout the CR), and control group (CR without diet). We measured hsCRP, leucocytes, neutrophils, IL-6, oxLDL, exercise capacity and classic risk factors before and after CR program.
Patients from the diet group presented with a significant decline in classic risk factors (BMI, waist circumference, waist to hip ratio, systolic blood pressure, heart rate, blood glucose, total cholesterol, LDL, TAG) and inflammatory markers (hsCRP, leucocytes, neutrophils) compared to control group. Furthermore, when studying nonsmokers, we observed significant decline of oxLDL in the diet group.
The addition of cardioprotective diet, rich with natural antioxidants, to physical activity as a part of a CR program, positively modifies not just classic risk factors and exercise capacity, but also diminishes chronic inflammation markers. These effects, and oxLDL decline were most prominent in nonsmoking patients.
慢性炎症是动脉粥样硬化的基本发病过程，可通过药物和非药物措施进行调节，作为急性心肌梗死（AMI）后二级预防的一部分。我们研究的目的是确定富含天然抗氧化剂的饮食添加到体育活动（作为心脏康复（CR）计划的一部分）对炎症标志物和氧化应激标志物氧化型低密度脂蛋白（ox-LDL）的影响，氧化型低密度脂蛋白与慢性炎症过程密切相关。
41例接受CR的AMI后男性患者被分为饮食组（在整个CR过程中接受监督的心脏保护饮食）和对照组（无饮食的CR）。我们在CR计划前后测量了高敏C反应蛋白（hsCRP）、白细胞、中性粒细胞、白细胞介素-6（IL-6）、氧化型低密度脂蛋白（oxLDL）、运动能力和经典危险因素。
与对照组相比，饮食组患者的经典危险因素（体重指数、腰围、腰臀比、收缩压、心率、血糖、总胆固醇、低密度脂蛋白、甘油三酯）和炎症标志物（hsCRP、白细胞、中性粒细胞）显著下降。此外，在研究非吸烟者时，我们观察到饮食组氧化型低密度脂蛋白显著下降。
在作为CR计划一部分的体育活动中添加富含天然抗氧化剂的心脏保护饮食，不仅能积极改善经典危险因素和运动能力，还能减少慢性炎症标志物。这些作用以及氧化型低密度脂蛋白的下降在非吸烟患者中最为显著。
