Gal Pim, Ooms Joris F W, Ottervanger Jan Paul, Smit Jaap Jan J, Adiyaman Ahmet, Ramdat Misier Anand R, Delnoy Peter Paul H M, Jager Piet L, Elvan Arif
Department of Cardiology, Isala Hospital, Zwolle, The Netherlands.
Department of Nuclear Medicine, Isala Hospital, Zwolle, The Netherlands.
Int J Cardiol Heart Vasc. 2015 Apr 17;8:1-5. doi: 10.1016/j.ijcha.2015.03.009. eCollection 2015 Sep 1.
We hypothesized that pulmonary vein (PV) orientation influences tissue contact of the contact force (CF) sensing radiofrequency ablation catheter (CFC) and therefore atrial fibrillation (AF) free survival after pulmonary vein isolation (PVI). The aim of this study was to determine the association between PV orientation, CF and AF free survival in patients undergoing CFC PVI.
Sixty consecutive patients undergoing CFC PVI were included. ECG-triggered cardiac CT scans were obtained in all patients before PVI, and the PV orientation was measured at the insertion in the LA for all PVs in both the transverse and frontal plane. PVs were assigned to 1 of 4 orientation groups: ventral-caudal, dorsal-caudal, ventral-cranial and dorsal-cranial.
Mean age was 59 years, 88% had paroxysmal AF. AF free survival off anti-arrhythmic drugs after a median follow-up of 12 months was 58% after a single PVI procedure. No association was found between PV orientation and CF. Furthermore, no association was found between PV orientation and AF free survival. In univariate analysis, the number of lesions with a mean CF of 10 g was associated with AF free survival. However, in multivariate analysis, only the AF duration was significantly associated with AF free survival.
This study shows that in patients undergoing PVI with the CFC ablation system, PV orientation does not affect CF and is not associated with AF free survival. PV orientation assessment does not appear to be necessary in patients undergoing CFC PVI.
我们假设肺静脉(PV)的方向会影响接触力(CF)感知型射频消融导管(CFC)与组织的接触,进而影响肺静脉隔离(PVI)术后无房颤(AF)生存情况。本研究旨在确定接受CFC PVI治疗的患者中PV方向、CF与无AF生存之间的关联。
纳入连续60例接受CFC PVI治疗的患者。所有患者在PVI术前均进行了心电图触发的心脏CT扫描,并在左心房(LA)插入处测量了所有PV在横切面和额面的方向。PV被分为4个方向组之一:腹侧-尾侧、背侧-尾侧、腹侧-头侧和背侧-头侧。
平均年龄为59岁,88%为阵发性AF。单次PVI术后,中位随访12个月时,停用抗心律失常药物后的无AF生存率为58%。未发现PV方向与CF之间存在关联。此外,也未发现PV方向与无AF生存之间存在关联。在单因素分析中,平均CF为10 g的消融灶数量与无AF生存相关。然而,在多因素分析中,只有AF持续时间与无AF生存显著相关。
本研究表明,在使用CFC消融系统进行PVI的患者中,PV方向不影响CF,且与无AF生存无关。对于接受CFC PVI治疗的患者,似乎没有必要进行PV方向评估。