Early use of beta blockers in patients with cocaine associated chest pain.

BACKGROUND

The most common symptom of cocaine abuse is chest pain. Cocaine induced chest pain (CICP) shares patho-physiological pathways with the acute coronary syndromes (ACS). A key event is the increase of activity of the adrenergic system. Beta blockers (BBs), a cornerstone in the treatment of ACS, are felt to be contraindicated in the patient with CICP due to a potential of an "unopposed alpha adrenergic effect (UAE)".

OBJECTIVES

Identify signs of UAE and in-hospital complications in patients who received BB while having cocaine induced chest pain.

METHODS

We performed a retrospective review of 378 patients admitted to a medical unit because of CICP. Twenty six of these were given a BB at the time of admission while having CICP. We compared these patients to a control group paired by age, sex, race and history of hypertension who did not received a BB while having CICP. Blood pressure, heart rate, length of stay and in-hospital cardiovascular complications were compared.

RESULTS

No statistically significant differences were found between the two groups except for a longer length of stay in the case group. This was felt to be due to unrelated causes.

CONCLUSIONS

This study does not support the presence of an UAE in patients with continuing CICP and treated early with BB. There were no in-hospital cardiovascular complications in the group of patients who had an early dose of BB while having CICP.

IMPLICATIONS

BB appeared safe when given early on admission to patients with CICP.