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胎儿酒精综合征并非产前酒精暴露的唯一后果。

[Fetal alcohol syndrome is not the only consequence of prenatal alcohol exposure].

作者信息

Sarman Ihsan, Rangmar Jenny

机构信息

Karolinska Institutet Department of Clinical Science and Education Sodersjukhuset - Sachsska barn- och ungdomssjukhus Stockholm, Sweden Karolinska Institutet Department of Clinical Science and Education Sodersjukhuset - Sachsska barn- och ungdomssjukhus Stockholm, Sweden.

Goteborgs universitet Samhallsvetenskapliga fakulteten - Goteborg, Sweden Goteborgs universitet Samhallsvetenskapliga fakulteten - Goteborg, Sweden.

出版信息

Lakartidningen. 2017 Aug 3;114:ERIA.

Abstract

Fetal alcohol syndrome is not the only consequence of prenatal alcohol exposure  The prevalence of fetal alcohol syndrome and fetal alcohol spectrum disorders in larger communities in USA is now updated to 0.4 % and 4.8 % respectively. Affected individuals bear witness to disease symptoms from many organ systems in addition to the brain and behavioural dysfunctions. In the light of modern epigenetic research, early alcohol exposure appears to play a hidden role in fetal reprogramming. The underlying mechanisms explain the »developmental origin of health and disease«, which has an impact on complex interactions between genome, environment and epigenetics.

摘要

胎儿酒精综合征并非孕期酒精暴露的唯一后果。美国较大社区中胎儿酒精综合征和胎儿酒精谱系障碍的患病率现已分别更新为0.4%和4.8%。除大脑和行为功能障碍外,受影响个体还出现了许多器官系统的疾病症状。根据现代表观遗传学研究,早期酒精暴露似乎在胎儿重编程中发挥着隐藏作用。其潜在机制解释了“健康与疾病的发育起源”,这对基因组、环境和表观遗传学之间的复杂相互作用产生影响。

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