铜催化环化反应用于构建 6H-色烯并[4,3-b]喹啉-6-酮：DMF 作为碳源的应用。
Copper-Catalyzed Cyclization for Access to 6H-Chromeno[4,3-b]quinolin-6-ones Employing DMF as the Carbon Source.
机构信息
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology , Hangzhou 310014, People's Republic of China.
出版信息
J Org Chem. 2017 Sep 1;82(17):9047-9053. doi: 10.1021/acs.joc.7b01515. Epub 2017 Aug 16.
PMID:28787167
Abstract
The first example of the copper-catalyzed cyclization of 4-(phenylamino)-2H-chromen-2-ones employing the N-methyl moiety of DMF as the source of the methine (CH) group has been developed, providing an efficient synthetic pathway to access novel functionalized 6H-chromeno[4,3-b]quinolin-6-ones in moderate to good yields.
摘要
首次发展了铜催化的 4-(苯氨基)-2H-色烯-2-酮的环化反应，利用 DMF 的 N-甲基作为亚甲基（CH）基团的来源，为获得新型功能化的 6H-色烯并[4,3-b]喹啉-6-酮提供了一种有效且温和的合成途径，产率中等至良好。
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