3-氯乙酰吡啶腺嘌呤二核苷酸磷酸，一种烟酰胺腺嘌呤二核苷酸磷酸（NADP+）的烷基化类似物。
3-Chloroacetylpyridine adenine dinucleotide phosphate, an alkylating analogue of NADP+.
作者信息
Biellmann J F, Eid P, Goulas P R, Hirth C
出版信息
Biochimie. 1978;60(4):417-9. doi: 10.1016/s0300-9084(78)80676-2.
PMID:28788
Abstract
An alkylating analogue of NADP+ the 3-chloroacetylpyridine adenine dinucleotide phosphate was prepared from 3-diazoacetylpyridine adenine dinucleotide phosphate which was obtained by enzymatic transglucosidation of NADP+. The 3-diazoacetylpyridine adenine dinucleotide phosphate proved to be more unstable when compared to the corresponding NAD+ analogue. The alkylation of several dehydrogenases using this alkylating analogue is mentioned.
摘要
烟酰胺腺嘌呤二核苷酸磷酸（NADP+）的一种烷基化类似物，即3-氯乙酰吡啶腺嘌呤二核苷酸磷酸，是由3-重氮乙酰吡啶腺嘌呤二核苷酸磷酸制备而成，而3-重氮乙酰吡啶腺嘌呤二核苷酸磷酸是通过NADP+的酶促转葡糖基化反应得到的。与相应的烟酰胺腺嘌呤二核苷酸（NAD+）类似物相比，3-重氮乙酰吡啶腺嘌呤二核苷酸磷酸被证明更不稳定。文中提到了使用这种烷基化类似物对几种脱氢酶进行烷基化的情况。
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