Synthesis and pharmacological evaluation of cyclic and opened thioanalogues of piperoxan.
作者信息
Strappaghetti G, Brasili L
出版信息
Farmaco Sci. 1986 Oct;41(10):794-800.
PMID:2878824
Abstract
Three piperoxan analogues, derived from the opening of the benzodioxane ring and/or replacement of the oxygen atom with the less polar sulfur, were synthesized. The decrease of the alpha-blocking activity found for these compounds showed that the binding site of benzodioxane-like compounds does not accept the substitution with less polar groups.
摘要
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