一些带有萘并二氧杂环戊烷核的WB4101类似物的合成与药理评价
Synthesis and pharmacological evaluation of some WB4101 analogues bearing a naphthodioxanic nucleus.
作者信息
Castagnino E, Strappaghetti G, Corsano S, Gallucci P, Brasili L, Giardinà D
出版信息
Farmaco Sci. 1984 Jul;39(7):569-74.
PMID:6148262
Abstract
Three WB4101 analogues, bearing a 1,4-naphthodioxanic system, were synthesized. The decrease of the alpha-blocking activity found for these compounds, showed that extension of the aromatic area in the dioxanic moiety of such benzodioxanic derivative, hinders the drug-receptor interaction.
摘要
合成了三种带有1,4-萘并二氧杂环戊烷体系的WB4101类似物。这些化合物的α-阻断活性降低，表明在此类苯并二氧杂环戊烷衍生物的二氧杂环戊烷部分扩展芳香区域会阻碍药物与受体的相互作用。
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