Bansal N, Majumdar S, Chakravarti R N
Int J Fertil. 1986 Sep-Oct;31(4):298-304.
Male rhesus monkeys were used to elucidate the combined effect of vasectomy and diabetes on frequency and size of atherosclerotic plaques. Four groups were made: in two, bilateral vasectomy was performed, and the other two were subjected to sham vasectomy. Half of the vasectomized and sham-vasectomized monkeys were made diabetic by intravenous injection of alloxan. The animals were observed for a period of one year. Clinical examination revealed bilateral cataract in 40% of the diabetic animals. Marked hyperglycemia along with significant increase of serum triglycerides and free fatty acids was noted in diabetic monkeys. Vasectomy per se did not alter serum lipid levels and overall atherosclerotic plaque score in nondiabetic monkeys. However, the combination of vasectomy with diabetic state led to significant increase of overall atherosclerotic plaque score in coronary and renal arteries.
雄性恒河猴被用于阐明输精管切除术和糖尿病对动脉粥样硬化斑块的频率和大小的联合影响。实验分为四组：两组进行双侧输精管切除术，另外两组进行假输精管切除术。在输精管切除组和假输精管切除组的猴子中，各有一半通过静脉注射四氧嘧啶诱导糖尿病。对这些动物进行了为期一年的观察。临床检查发现，40%的糖尿病动物出现双侧白内障。糖尿病猴子出现明显的高血糖，同时血清甘油三酯和游离脂肪酸显著增加。输精管切除术本身并未改变非糖尿病猴子的血脂水平和总体动脉粥样硬化斑块评分。然而，输精管切除术与糖尿病状态相结合导致冠状动脉和肾动脉的总体动脉粥样硬化斑块评分显著增加。
