解开 tau 病谜团：tau 病理学和神经退行性变的当前概念。

Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration.

机构信息

Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London, London, UK; Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK.

出版信息

Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S34-S38. doi: 10.1016/j.parkreldis.2017.07.031. Epub 2017 Aug 1.

DOI:10.1016/j.parkreldis.2017.07.031

PMID:28789904

Abstract

Tau is the most common misfolded protein responsible for human neurodegenerative diseases. The identification of mutations in MAPT, the gene that encodes tau, causing dementia and parkinsonism established the notion that tau aggregation is responsible for the development of disease. An increased understanding of the pathway leading from conformational changes in tau protein and tau propagation to neuronal dysfunction, cell death and clinical manifestation will be the key for the development mechanism-based therapeutic strategies for tauopathies.

摘要

tau 是最常见的错误折叠蛋白，导致人类神经退行性疾病。在 MAPT 基因突变，即编码 tau 的基因导致痴呆和帕金森病被发现后，tau 聚集被认为是导致疾病发展的原因。增加对 tau 蛋白构象变化和 tau 传播导致神经元功能障碍、细胞死亡和临床表现的途径的理解，将是开发针对 tau 病的基于机制的治疗策略的关键。