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一种使用压缩髂嵴同种异体骨进行枕颈融合的改良技术在儿童人群中融合率较高。

A Modified Technique for Occipitocervical Fusion Using Compressed Iliac Crest Allograft Results in a High Rate of Fusion in the Pediatric Population.

作者信息

Iyer Rajiv R, Tuite Gerald F, Meoded Avner, Carey Carolyn C, Rodriguez Luis F

机构信息

Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.

Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA; Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

出版信息

World Neurosurg. 2017 Nov;107:342-350. doi: 10.1016/j.wneu.2017.07.172. Epub 2017 Aug 5.

Abstract

BACKGROUND

In children, high rates of occipitocervical (OC) fusion have been demonstrated with the use of rigid instrumentation in combination with harvested autograft, with or without bone morphogenetic protein (BMP). Historically, the use of allograft materials demonstrated inferior OC fusion outcomes compared with autograft. However, autograft harvest harbors an increased risk of patient morbidity, and the use of BMP is costly and controversial in children. Thus, there remains a need for safer, less costly, yet efficacious techniques for OC fusion in the pediatric population.

METHODS

We retrospectively reviewed the charts of patients younger than 21 years of age who underwent OC fusion with structural allograft placement at our institution from 2010 to 2015. Data collected included age, sex, follow-up duration, fusion outcomes, and postoperative complications.

RESULTS

A total of 19 patients (8 female and 11 male) underwent OC fusion with our surgical technique. Mean age was 8.5 ± 4.3 years. Radiographic follow up data were available for 18 of 19 patients. One patient was lost to clinical follow up but had radiographic confirmation of fusion. Thus, 18 of 18 (100%) of patients with radiographic follow-up achieved successful arthrodesis as determined by computed tomography. Median duration to documented fusion was 4.5 months. Clinical follow-up was available for 17 of 19 patients and was on average 18.8 ± 13.5 months. One patient required reoperation for graft fracture 8 months after radiographic confirmation of successful fusion. There were no vertebral artery injuries or other postoperative complications.

CONCLUSIONS

We demonstrate a modified technique for OC fusion in children with unique structural allograft shaping and affixation, leading to excellent fusion outcomes at follow up. This technique obviates the need for autograft harvest or BMP, and may decrease postoperative morbidity.

摘要

背景

在儿童中,已证明使用刚性器械结合自体骨移植(无论是否使用骨形态发生蛋白[BMP])进行枕颈(OC)融合的成功率较高。从历史上看,与自体骨移植相比,同种异体移植材料的OC融合效果较差。然而,自体骨移植会增加患者发病的风险,并且在儿童中使用BMP成本高昂且存在争议。因此,仍需要更安全、成本更低但有效的技术用于儿科人群的OC融合。

方法

我们回顾性分析了2010年至2015年在本机构接受OC融合并植入结构性同种异体骨的21岁以下患者的病历。收集的数据包括年龄、性别、随访时间、融合结果和术后并发症。

结果

共有19例患者(8例女性和11例男性)接受了我们的手术技术进行OC融合。平均年龄为8.5±4.3岁。19例患者中有18例有影像学随访数据。1例患者失访,但影像学证实融合。因此,在接受影像学随访的18例患者中,18例(100%)通过计算机断层扫描确定成功实现了关节融合。记录到融合的中位时间为4.5个月。19例患者中有17例有临床随访,平均随访时间为18.8±13.5个月。1例患者在影像学证实成功融合8个月后因移植骨骨折需要再次手术。没有椎动脉损伤或其他术后并发症。

结论

我们展示了一种改良技术,用于儿童OC融合,采用独特的结构性同种异体骨塑形和固定方法,随访时融合效果良好。该技术无需自体骨移植或BMP,可能会降低术后发病率。

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