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一些选择性毒蕈碱受体拮抗剂对介导兔和大鼠胸主动脉内皮依赖性舒张的毒蕈碱受体的亲和力。

The affinity of some selective muscarinic receptor antagonists for the muscarinic receptor mediating endothelial-dependent relaxation of the rabbit and rat thoracic aorta.

作者信息

Choo L K, Malta E, Mitchelson F

出版信息

J Pharm Pharmacol. 1986 Nov;38(11):843-5. doi: 10.1111/j.2042-7158.1986.tb04507.x.

DOI:10.1111/j.2042-7158.1986.tb04507.x
PMID:2879017
Abstract

The pKB values determined for pirenzepine, 4-DAMP, secoverine and gallamine against acetylcholine-mediated relaxant effects in rabbit aorta indicate that this muscarinic receptor closely resembles that which mediates contraction of non-vascular smooth muscle. The results of the present study argue against the presence of a novel type of muscarinic receptor mediating endothelium-dependent relaxation.

摘要

在兔主动脉中，针对哌仑西平、4-二甲基氨基吡啶（4-DAMP）、西维美林和加拉明对乙酰胆碱介导的舒张作用所测定的pKB值表明，这种毒蕈碱受体与介导非血管平滑肌收缩的受体极为相似。本研究结果反对存在一种介导内皮依赖性舒张的新型毒蕈碱受体。

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The affinity of some selective muscarinic receptor antagonists for the muscarinic receptor mediating endothelial-dependent relaxation of the rabbit and rat thoracic aorta.一些选择性毒蕈碱受体拮抗剂对介导兔和大鼠胸主动脉内皮依赖性舒张的毒蕈碱受体的亲和力。
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引用本文的文献

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Release of endothelium-derived hyperpolarizing factor (EDHF) by M3 receptor stimulation in guinea-pig coronary artery.豚鼠冠状动脉中M3受体刺激引发内皮源性超极化因子（EDHF）的释放。
Br J Pharmacol. 1995 Jul;115(5):717-22. doi: 10.1111/j.1476-5381.1995.tb14992.x.
2
The interaction of methoctramine and himbacine at atrial, smooth muscle and endothelial muscarinic receptors in vitro.甲氧卡明与辛巴辛在体外对心房、平滑肌和内皮毒蕈碱受体的相互作用。
Br J Pharmacol. 1988 Dec;95(4):1031-8. doi: 10.1111/j.1476-5381.1988.tb11736.x.
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Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):246-9. doi: 10.1007/BF00173395.
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The interaction of parafluorohexahydrosiladiphenidol at muscarinic receptors in vitro.对氟六氢硅二苯胺醇在体外与毒蕈碱受体的相互作用。
Br J Pharmacol. 1990 Apr;99(4):637-42. doi: 10.1111/j.1476-5381.1990.tb12983.x.
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Radioligand binding to muscarinic receptors of bovine aortic endothelial cells.放射性配体与牛主动脉内皮细胞毒蕈碱受体的结合
Br J Pharmacol. 1991 Feb;102(2):373-80. doi: 10.1111/j.1476-5381.1991.tb12181.x.
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Inhibition of endothelium-dependent vasorelaxation by arginine analogues: a pharmacological analysis of agonist and tissue dependence.精氨酸类似物对内皮依赖性血管舒张的抑制作用：激动剂和组织依赖性的药理学分析
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