一些选择性毒蕈碱受体拮抗剂对介导兔和大鼠胸主动脉内皮依赖性舒张的毒蕈碱受体的亲和力。
The affinity of some selective muscarinic receptor antagonists for the muscarinic receptor mediating endothelial-dependent relaxation of the rabbit and rat thoracic aorta.
作者信息
Choo L K, Malta E, Mitchelson F
出版信息
J Pharm Pharmacol. 1986 Nov;38(11):843-5. doi: 10.1111/j.2042-7158.1986.tb04507.x.
Abstract
The pKB values determined for pirenzepine, 4-DAMP, secoverine and gallamine against acetylcholine-mediated relaxant effects in rabbit aorta indicate that this muscarinic receptor closely resembles that which mediates contraction of non-vascular smooth muscle. The results of the present study argue against the presence of a novel type of muscarinic receptor mediating endothelium-dependent relaxation.
摘要
在兔主动脉中，针对哌仑西平、4-二甲基氨基吡啶（4-DAMP）、西维美林和加拉明对乙酰胆碱介导的舒张作用所测定的pKB值表明，这种毒蕈碱受体与介导非血管平滑肌收缩的受体极为相似。本研究结果反对存在一种介导内皮依赖性舒张的新型毒蕈碱受体。
Zotero 插件