Koo M W, Cho C H, Ogle C W
J Pharm Pharmacol. 1986 Nov;38(11):845-8. doi: 10.1111/j.2042-7158.1986.tb04508.x.
The role of luminal acid and the influence of the antisecretory action of verapamil in stress ulcer prevention in rat stomachs have been studied. Intraperitoneally injected verapamil, 4 mg kg-1, inhibited gastric acid secretion and ulcer formation, however, a 2 mg kg-1 dose, which did not significantly influence acid output, also had an antiulcer effect. Intraperitoneal injection of bethanechol, 1.2 or 3.6 mg kg-1, increased gastric acid output, but did not influence stress-induced ulcer formation. Oral administration of HCl, 25 or 50 mu equiv, aggravated stress ulceration in a dose-dependent manner; this lesion-worsening effect was prevented by pretreatment with verapamil or bethanechol. The gastric luminal acid content in 2 h pylorus-ligated rats was similar in the groups given either bethanechol or HCl. These findings indicate that the antisecretory action of verapamil may not account for its antiulcer effect. It is suggested that endogenous and exogenous luminal acid may have different influences on stress ulcer formation.
研究了管腔酸的作用以及维拉帕米的抗分泌作用对大鼠胃应激性溃疡预防的影响。腹腔注射4mg/kg维拉帕米可抑制胃酸分泌和溃疡形成，然而，2mg/kg剂量对酸分泌无显著影响，但也具有抗溃疡作用。腹腔注射1.2或3.6mg/kg氨甲酰甲胆碱可增加胃酸分泌，但不影响应激性溃疡的形成。口服25或50微当量盐酸可剂量依赖性地加重应激性溃疡；维拉帕米或氨甲酰甲胆碱预处理可预防这种损伤加重效应。在给予氨甲酰甲胆碱或盐酸的组中，2小时幽门结扎大鼠的胃管腔酸含量相似。这些发现表明，维拉帕米的抗分泌作用可能无法解释其抗溃疡作用。提示内源性和外源性管腔酸可能对应激性溃疡的形成有不同影响。
