细胞核中的肌动蛋白：肌动蛋白结构的调控调节间充质干细胞分化。
Actin up in the Nucleus: Regulation of Actin Structures Modulates Mesenchymal Stem Cell Differentiation.
作者信息
Rubin Janet, Sen Buer
机构信息
CHAPEL HILL, NORTH CAROLINA.
出版信息
Trans Am Clin Climatol Assoc. 2017;128:180-192.
Abstract
Stem cells respond to environmental signals that induce their differentiation to cells that make up specialized tissues and organs. Our laboratory has focused on bone marrow mesenchymal stem cells (MSCs) that supply bone osteoblasts and marrow adipocytes, an output that appears to be reciprocal. Case in point: exercise promotes osteogenesis and bone formation, and inhibits marrow adipose accrual. A mechanically induced signal pathway concentrating on preserving β-catenin also causes increased structure of the actin cytoskeleton, both of which inhibit adipogenesis. Recently we showed that intranuclear actin is as important to MSC lineage decisions as cytoplasmic actin. This opens up new areas for understanding gene expression in stem cells.
摘要
干细胞会对环境信号作出反应，这些信号会诱导它们分化为构成专门组织和器官的细胞。我们的实验室一直专注于骨髓间充质干细胞（MSC），它们可产生骨成骨细胞和骨髓脂肪细胞，而这两种细胞的生成似乎是相互关联的。例如：运动可促进骨生成和骨形成，并抑制骨髓脂肪堆积。一条专注于维持β-连环蛋白的机械诱导信号通路也会导致肌动蛋白细胞骨架结构增加，这两者都会抑制脂肪生成。最近我们发现，核内肌动蛋白对MSC谱系决定的重要性与胞质肌动蛋白相当。这为理解干细胞中的基因表达开辟了新领域。
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