Misra R N, Chander Yogesh, Debata N K, Ohri V C
Classified Specialist(Pathology and Microbiology), INHS Asvini, Colaba, Mumbai-400 005.
Reader, Department of Microbiology, Armed Forces Medical College, Pune 411 040.
Med J Armed Forces India. 2000 Jul;56(3):205-208. doi: 10.1016/S0377-1237(17)30167-3. Epub 2017 Jun 10.
Two-hundred and eighty bacterial isolates from wound and soft tissue infections were studied for species identification and antibiotic resistance pattern. Amongst them 122 isolates were from community acquired infection and 158 were from nosocomial infections. The common community acquired pathogens were (67.8%) and (10.7%), whereas (60.1%) and (8.9%) were common in nosocomial infection. Only two anaerobes (Cl perfringens) were isolated. Penicillin resistance was found to be 87% and 92% for in community acquired and noscomial infections respectively. 85% of Proteus isolates were resistant to ampicillin. There was relatively lower level of resistance by all isolates to cefotaxime. Gentamicin showed higher rate of resistance than netilmicin and amikacin. Resistance of isolates to fluoroquinolones being 79% for norfloxacin, 81% for ciprofloxacin and 60% for ofloxacin. The study showed a higher resistance of methicillin resistant to other antibiotics. Amikacin and ofloxacin were the best recommended drugs for empirical therapy for all organisms, the susceptibility rate being 80.7% and 80.4%.
对280株来自伤口和软组织感染的细菌分离株进行了菌种鉴定和抗生素耐药模式研究。其中122株分离株来自社区获得性感染，158株来自医院感染。社区获得性感染的常见病原体为（67.8%）和（10.7%），而医院感染中常见的是（60.1%）和（8.9%）。仅分离出两种厌氧菌（产气荚膜梭菌）。在社区获得性感染和医院感染中，肺炎链球菌对青霉素的耐药率分别为87%和92%。85%的变形杆菌分离株对氨苄西林耐药。所有分离株对头孢噻肟的耐药水平相对较低。庆大霉素的耐药率高于奈替米星和阿米卡星。肺炎链球菌分离株对氟喹诺酮类药物的耐药率为：诺氟沙星79%，环丙沙星81%，氧氟沙星60%。研究表明，耐甲氧西林金黄色葡萄球菌对其他抗生素的耐药性较高。阿米卡星和氧氟沙星是对所有微生物经验性治疗的最佳推荐药物，药敏率分别为80.7%和80.4%。
