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正常妊娠18至40周时脐动脉和胎儿大脑中动脉的多普勒指数：一项初步研究。

Doppler indices of the umbilical and fetal middle cerebral artery at 18-40 weeks of normal gestation: A pilot study.

作者信息

Srikumar Satyabrat, Debnath Jyotindu, Ravikumar R, Bandhu H C, Maurya V K

机构信息

Graded Specialist (Radiology), SFF Hospital, Establishment No 22, C/o 56 APO, India.

Professor, Department of Radiodiagnosis, Armed Forces Medical College, Pune 411040, India.

出版信息

Med J Armed Forces India. 2017 Jul;73(3):232-241. doi: 10.1016/j.mjafi.2016.12.008. Epub 2017 Jan 17.

DOI:10.1016/j.mjafi.2016.12.008
PMID:28790780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5533518/
Abstract

BACKGROUND

Doppler indices form an integral component of noninvasive evaluation of fetal well-being. There is paucity of information about normal obstetric Doppler indices, particularly from the Indian subcontinent. The aim of the study was to find the values of pulsatility index (PI), resistive index (RI) of umbilical artery (UA), and fetal middle cerebral artery (MCA) and calculate cerebro-placental ratio (CP ratio) for 18-40 weeks of normal gestation so that a reference range of these Doppler values can be postulated.

METHODS

200 patients were enrolled in the study for color Doppler study of UA and MCA and were serially followed up at 4-6 weeks interval for Doppler indices. Angle-independent Doppler indices like PI and RI for MCA and UA were obtained during each examination. CP ratio was calculated in each case. All the cases were followed up till delivery and the perinatal outcome was recorded.

RESULTS & CONCLUSION: The fetal MCA PI and RI showed a parabolic curve with plateau at 28-30 weeks of gestation. A significant correlation was noted between MCA PI and RI with gestational age. UA PI and RI showed a gradual fall over the gestational age with a strong negative correlation. There was a significant correlation between MCA PI and UA PI with their respective RI values. CP ratio has also shown a parabolic curve with turning point at 31-32 weeks of gestation. A significant correlation was noted between CP ratio and gestational age. CP ratio also showed a minimal positive correlation with MCA PI and a strong negative correlation with UA PI.

摘要

背景

多普勒指数是非侵入性评估胎儿健康状况的重要组成部分。关于正常产科多普勒指数的信息匮乏，尤其是来自印度次大陆的信息。本研究的目的是确定正常妊娠18至40周时脐动脉（UA）和胎儿大脑中动脉（MCA）的搏动指数（PI）、阻力指数（RI）值，并计算脑胎盘比率（CP比率），以便推测这些多普勒值的参考范围。

方法

200名患者纳入本研究，接受UA和MCA的彩色多普勒检查，并每隔4至6周对多普勒指数进行连续随访。每次检查时获取MCA和UA的与角度无关的多普勒指数，如PI和RI。计算每个病例的CP比率。所有病例随访至分娩，并记录围产期结局。

结果与结论

胎儿MCA的PI和RI在妊娠2

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