Xia Likun, Li Shumei, Wang Tianyue, Guo Yaping, Meng Lihong, Feng Yunping, Cui Yu, Wang Fan, Ma Jian, Jiang Guihua
Department of Magnetic Resonance Imaging, People's Hospital of Yuxi City, Yuxi.
Department of Medical Imaging, Guangdong No 2 Provincial People's Hospital, Guangzhou.
Neuropsychiatr Dis Treat. 2017 Jul 20;13:1957-1965. doi: 10.2147/NDT.S133853. eCollection 2017.
We aimed to examine how spontaneous brain activity might be related to the pathophysiology of generalized anxiety disorder (GAD).
Using resting-state functional MRI, we examined spontaneous regional brain activity in 31 GAD patients (mean age, 36.87±9.16 years) and 36 healthy control participants (mean age, 39.53±8.83 years) matched for age, education, and sex from December 2014 to October 2015. We performed a two-sample -test on the voxel-based analysis of the regional homogeneity (ReHo) maps. We used Pearson correlation analysis to compare scores from the Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, State-Trait Anxiety Scale-Trait Scale, and mean ReHo values.
We found abnormal spontaneous activity in multiple regions of brain in GAD patients, especially in the sensorimotor cortex and emotional regions. GAD patients showed decreased ReHo values in the right orbital middle frontal gyrus, left anterior cingulate cortex, right middle frontal gyrus, and bilateral supplementary motor areas, with increased ReHo values in the left middle temporal gyrus, left superior temporal gyrus, and right superior occipital gyrus. The ReHo value of the left middle temporal gyrus correlated positively with the Hamilton Anxiety Rating Scale scores.
These results suggest that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of GAD.
我们旨在研究自发性脑活动可能如何与广泛性焦虑障碍（GAD）的病理生理学相关。
从2014年12月至2015年10月，我们使用静息态功能磁共振成像，检查了31例GAD患者（平均年龄36.87±9.16岁）和36名年龄、教育程度和性别相匹配的健康对照参与者（平均年龄39.53±8.83岁）的自发性局部脑活动。我们对基于体素的局部一致性（ReHo）图进行了双样本t检验。我们使用Pearson相关分析来比较汉密尔顿焦虑量表、汉密尔顿抑郁量表、状态-特质焦虑量表-特质量表的得分以及平均ReHo值。
我们发现GAD患者多个脑区存在异常的自发性活动，尤其是在感觉运动皮层和情感区域。GAD患者右侧眶额中回、左侧前扣带回皮层、右侧额中回和双侧辅助运动区的ReHo值降低，而左侧颞中回、左侧颞上回和右侧枕上回的ReHo值升高。左侧颞中回的ReHo值与汉密尔顿焦虑量表得分呈正相关。
这些结果表明，自发性脑活动的局部同步性改变可能与GAD的病理生理学相关。
