隐形护盾：角膜上皮作为紫外线辐射、病原体及其他环境刺激屏障的综述
Invisible Shield: Review of the Corneal Epithelium as a Barrier to UV Radiation, Pathogens, and Other Environmental Stimuli.
作者信息
Bashir Hasan, Seykora John T, Lee Vivian
机构信息
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA.
Department of Dermatology, University of Pennsylvania, Philadelphia, USA.
出版信息
J Ophthalmic Vis Res. 2017 Jul-Sep;12(3):305-311. doi: 10.4103/jovr.jovr_114_17.
The ocular surface is comprised of the cornea and conjunctiva, which are structures that not only protect the eye but also enable vision. The corneal epithelium is the most superficial layer of the cornea, and therefore first line of defense against external assaults. Damage to this highly specialized structure could lead to vision loss, making it an important structure to investigate and understand. Here, we conducted a search of the current literature on the mechanisms the corneal epithelium has adapted against three frequent insults: UV-radiation, pathogens, and environmental assaults. This review systematically examines the corneal epithelium's response to each assault in order to maintain its role as an invisible shield. The goal of this review is to provide insight into some of the critical functions the corneal epithelium performs that may be valuable to current regenerative studies.
眼表由角膜和结膜组成，这些结构不仅保护眼睛，还能实现视觉功能。角膜上皮是角膜最表层，因此是抵御外部侵害的第一道防线。这种高度专业化结构的损伤可能导致视力丧失，使其成为一个值得研究和了解的重要结构。在此，我们检索了当前关于角膜上皮针对三种常见侵害（紫外线辐射、病原体和环境侵害）所采用适应机制的文献。本综述系统地研究了角膜上皮对每种侵害的反应，以维持其作为无形屏障的作用。本综述的目的是深入了解角膜上皮所执行的一些关键功能，这些功能可能对当前的再生研究具有重要价值。
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