Naesgaard Patrycja A, Grundt Heidi, Nordøy Arne F, Staines Harry, Nilsen Dennis W T
Department of Cardiology, Stavanger University Hospital, Stavanger, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
Front Cardiovasc Med. 2017 Jul 24;4:41. doi: 10.3389/fcvm.2017.00041. eCollection 2017.
Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce.
We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction.
228 patients were randomized 1:1 to receive a daily dose of either 4 g omega-3 (OMACOR) or an equal dose of corn oil, administered double-blindly for 12 months. Total omega-3 and omega-6 measurements were available in 40 randomly picked patients.
There was no significant intergroup difference in 25(OH)D changes at 12 months follow-up ( = 0.12), but there was a minor statistical significant intragroup increase in 25(OH)D in both intervention arms ( < 0.001 for n-3 polyunsaturated fatty acids and = 0.013 for corn oil, respectively). A positive correlation was noted between 25(OH)D and omega-3 prior to inclusion; = 0.418, = 0.007, attenuated at 12 months by purified omega-3 intervention; = 0.021, = 0.93. No positive correlation was observed between omega-6 and 25(OH)D.
Long-term treatment with a high dose of purified omega-3 as compared to corn oil did not improve serum concentrations of vitamin D.
ClinicalTrials.gov, Identifier: NCT01422317.
鱼类是维生素D的天然膳食来源。关于纯化的ω-3脂肪酸对其吸收影响的报道很少。
我们研究了与玉米油相比，纯化的高剂量ω-3化合物对急性心肌梗死后25-羟基维生素D[25(OH)D]水平的影响。
228例患者按1:1随机分组，每日接受4gω-3（OMACOR）或等量玉米油，双盲给药12个月。对40例随机挑选的患者进行了总ω-3和ω-6测量。
在12个月的随访中，两组间25(OH)D变化无显著差异（=0.12），但两个干预组内25(OH)D均有轻微统计学意义的升高（n-3多不饱和脂肪酸组<0.001，玉米油组=0.013）。纳入前25(OH)D与ω-3呈正相关；=0.418，=0.007，在12个月时通过纯化的ω-3干预减弱；=0.021，=0.93。未观察到ω-6与25(OH)D之间的正相关。
与玉米油相比，高剂量纯化ω-3的长期治疗并未改善维生素D的血清浓度。
ClinicalTrials.gov，标识符：NCT01422317。
