系统性硬化症发病机制中的血管生成失调
Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis.
作者信息
Cantatore Francesco Paolo, Maruotti Nicola, Corrado Addolorata, Ribatti Domenico
机构信息
Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, Foggia, Italy.
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
出版信息
Biomed Res Int. 2017;2017:5345673. doi: 10.1155/2017/5345673. Epub 2017 Jul 16.
Abstract
Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.
摘要
系统性硬化症是一种慢性自身免疫性结缔组织疾病，其特征为血管损伤、纤维化以及血管生成受损，无法确保有效的血管修复。血管损伤导致缺氧和组织缺血，这是血管生成的主要触发因素，但无法诱导代偿性血管生成。这篇综述文章聚焦于系统性硬化症中血管生成失调机制的当前知识。
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Searching for a good model for systemic sclerosis: the molecular profile and vascular changes occurring in UCD-200 chickens strongly resemble the early phase of human systemic sclerosis.寻找系统性硬化症的良好模型：UCD - 200鸡身上出现的分子特征和血管变化与人类系统性硬化症的早期阶段极为相似。
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