高非对映选择性冠醚催化的 3-芳基邻苯二甲酸酐的芳基迈克尔反应。
Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3-Aryl Phthalides.
机构信息
Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno , Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy.
出版信息
Org Lett. 2017 Aug 18;19(16):4383-4386. doi: 10.1021/acs.orglett.7b02113. Epub 2017 Aug 9.
PMID:28792223
Abstract
The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or KPO and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as single diastereomers in nearly all studied cases.
摘要
开发了 3-芳基苯并呋喃的首例芳基类似迈克尔反应。在催化量的 KOH 或 KPO 和二苯并-18-冠-6 的促进下，该反应以良好至高产率得到相应的 3,3-二取代苯并呋喃，并且在几乎所有研究的情况下均以近乎单一非对映异构体的形式得到产物。
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