c-erb-A蛋白是甲状腺激素的高亲和力受体。
The c-erb-A protein is a high-affinity receptor for thyroid hormone.
作者信息
Sap J, Muñoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennström B
出版信息
Nature. 1986;324(6098):635-40. doi: 10.1038/324635a0.
DOI:10.1038/324635a0
PMID:2879242
Abstract
Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.
摘要
激素结合以及c-erb-A蛋白的定位表明它是甲状腺激素的受体，是一种能与DNA结合并激活转录的核蛋白。相比之下，病毒癌基因v-erb-A的产物在结合激素方面存在缺陷，但仍位于细胞核中。
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