Guttier Marília Cruz, Silveira Marysabel Pinto Telis, Luiza Vera Lucia, Bertoldi Andréa Dâmaso
Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas (UFPel). R. Marechal Deodoro 1160/313, Centro. 96020-220 Pelotas RS Brasil.
Departamento de Fisiologia e Farmacologia, Instituto de Biologia, UFPel. Pelotas RS Brasil.
Cien Saude Colet. 2017 Aug;22(8):2627-2644. doi: 10.1590/1413-81232017228.05762017.
The need to increase access to medicines, coupled with the limited acceptance of generics has sparked the search for effective interventions to promote it. This systematic review aimed to conduct a survey on interventions to promote the use of generic drugs and its impact. Randomized clinical trials, non-randomized controlled trials, controlled before-after studies and interrupted time series were included. The analysis of the impact of interventions and quality of evidence followed Cochrane's guidelines. Impact of interventions was rated from "very large" to "very small" and the quality of evidence was rated from "high" to "very low". Seventeen papers addressing prescribers, pharmacists and users were selected. There were educational, financial incentives and use of electronic prescription and managerial interventions. Interventions applied to prescribers had little to medium impact, with very low-to-low quality evidence. Interventions applied to pharmacists had small impact with very low quality evidence. Interventions applied to users had medium and large impact with very low-to-low quality evidence. Further studies with good quality addressing interventions are required.
增加药品可及性的需求，再加上对仿制药的接受度有限，引发了人们对促进仿制药使用的有效干预措施的探索。本系统评价旨在对促进使用仿制药的干预措施及其影响进行调查。纳入了随机临床试验、非随机对照试验、前后对照研究和中断时间序列研究。对干预措施的影响和证据质量的分析遵循Cochrane指南。干预措施的影响从“非常大”到“非常小”进行评级，证据质量从“高”到“非常低”进行评级。选择了17篇针对开处方者、药剂师和使用者的论文。有教育、经济激励、电子处方的使用和管理干预措施。应用于开处方者的干预措施影响小到中等，证据质量非常低到低。应用于药剂师的干预措施影响小，证据质量非常低。应用于使用者的干预措施影响中等和大，证据质量非常低到低。需要开展更多高质量的关于干预措施的研究。
