Green P G, Kitchen I
Toxicology. 1986 Dec 15;42(2-3):275-80. doi: 10.1016/0300-483x(86)90015-6.
The irreversible anticholinesterase, di-isopropylfluorophosphate (DFP), was shown to be antinociceptive in the paw pressure test in rats only at doses where animals exhibited marked signs of anticholinesterase poisoning. At sub-antinociceptive doses DFP potentiated the opioid drugs fentanyl and alfentanil but failed to alter morphine antinociception. These interactions differ from our previous studies using the hot plate test in mice and suggest that opioid/cholinergic interactions are species and test dependent.
不可逆性抗胆碱酯酶二异丙基氟磷酸酯（DFP）仅在动物表现出明显抗胆碱酯酶中毒迹象的剂量下，才在大鼠爪部压力试验中显示出抗伤害感受作用。在低于抗伤害感受剂量时，DFP增强了阿片类药物芬太尼和阿芬太尼的作用，但未能改变吗啡的抗伤害感受作用。这些相互作用与我们之前使用小鼠热板试验的研究不同，表明阿片类/胆碱能相互作用具有物种和试验依赖性。
