Green P G, Kitchen I
Department of Biochemistry, University of Surrey, Guildford, UK.
J Pharm Pharmacol. 1988 Apr;40(4):292-3. doi: 10.1111/j.2042-7158.1988.tb05249.x.
Di-isopropylfluorophosphate (DFP) displaced the opioid drug, alfentanil, from plasma proteins in-vivo and in-vitro in mice but was without effect on the structurally related compound, fentanyl. This action probably accounts for the enhanced entry of alfentanil into the brain of DFP-treated animals and its enhanced antinociceptive activity.
二异丙基氟磷酸酯（DFP）在体内和体外均可使小鼠血浆蛋白中的阿片类药物阿芬太尼发生置换，但对结构相关化合物芬太尼无影响。这种作用可能是DFP处理的动物脑内阿芬太尼进入量增加及其镇痛活性增强的原因。
