历史视角：帕金森病传统结局指标的利弊。
Historical perspective: The pros and cons of conventional outcome measures in Parkinson's disease.
机构信息
Division of Neurology, The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.
Division of Neurology, The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S47-S52. doi: 10.1016/j.parkreldis.2017.07.029. Epub 2017 Jul 29.
BACKGROUND
Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment.
METHODS
It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital technologies - to review the strengths and weaknesses of these outcome measures.
RESULTS
This paper discusses advances (including an enhanced understanding of PD itself, and the development of clinimetrics as a field) that have led to improvements in the COMs used in PD; their strengths and limitations; and factors to consider when selecting and using a measuring instrument.
CONCLUSIONS
It is envisaged that in the future, a combination of COMs and technology-based objective measures will be utilized, with different methods having their own strengths and weaknesses. Judgement is required on the part of the clinician and researcher in terms of which instrument(s) are appropriate to use, depending on the particular clinical or research setting or question.
背景
帕金森病（PD）的传统疗效评估指标（COMs）指的是那些不需要特殊设备的评分量表、问卷、患者日记和基于临床的测试。
方法
此时恰逢临床医生和研究人员开始应对数字技术的“入侵”，因此有必要回顾这些疗效评估指标的优缺点。
结果
本文讨论了一些进展（包括对 PD 本身的认识加深，以及临床计量学领域的发展），这些进展使得 PD 中使用的 COMs 得到了改进；讨论了它们的优缺点；以及在选择和使用测量仪器时需要考虑的因素。
结论
可以预见，在未来，将同时使用 COMs 和基于技术的客观测量方法，不同的方法各有优缺点。取决于特定的临床或研究背景或问题，临床医生和研究人员需要根据情况判断使用哪种（或哪些）仪器。
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